The main reason why diabetic patients experience slow wound healing is due to the presence of high levels of glucose in the bloodstream. This excess glucose can damage blood vessels, impair circulation, and impair the immune system’s ability to fight off infections. DMSO has been shown to have an antioxidant effect, reducing oxidative stress caused by high glucose levels, and enhancing the body’s natural healing mechanisms.
One of the ways DMSO helps to improve wound healing is by reducing inflammation. Chronic inflammation is a common feature of diabetic wounds, which can prevent the healing process from taking place. DMSO has anti-inflammatory properties that can help reduce inflammation and promote tissue regeneration. In a study conducted on diabetic rats, dmso toxicity was shown to reduce the levels of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines, resulting in faster wound healing.
DMSO has also been found to enhance the skin’s permeability, making it easier for drugs and other healing agents to penetrate the skin and reach the underlying tissue. This property can be especially useful in diabetic wounds, where impaired blood flow can make it difficult for topical treatments to reach the affected area. In one study, researchers applied a DMSO-based gel to the wounds of diabetic rats and found that it significantly enhanced the penetration of a topical antibiotic, resulting in faster healing and reduced inflammation.
One of the main controversies surrounding the use of DMSO in medicine is its safety. DMSO has been shown to have a wide range of potential side effects, including skin irritation, headache, dizziness, and nausea. Additionally, DMSO has been shown to have teratogenic and mutagenic effects in animal studies, raising concerns about its safety for use in humans. These safety concerns have led some medical professionals to question the use of DMSO in medicine.
Another controversy surrounding the use of DMSO in medicine is its regulatory status. In the United States, DMSO is classified as a solvent and is not approved by the Food and Drug Administration (FDA) for any specific medical use. This means that the use of DMSO in medicine is considered “off-label,” which can raise legal and ethical concerns. Some medical professionals argue that the lack of FDA approval for DMSO use in medicine makes it difficult to evaluate its safety and efficacy.